Bertille Bak, « Circuits »

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Cancer chemoresistance and BAK

Blocking or evading apoptosis is one of the hallmarks of cancer [1]. Recent advances in genomic sequencing have identified many mutations in cancer cells, prompting an increased effort to identify driver mutations in critical pathways that impact upon cell survival. Interestingly though, many cancers have intact apoptotic machinery where mutation rates of key regulators is very low the BCL-2 fa...

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Bak - Sneppen Model

R. Cafiero, P. De Los Rios, A. Valleriani, and J. L. Vega 1 P.M.M.H., Ecole Supérieure de Physique et de chimie Industrielles, 10, rue Vaquelin, 75231 Paris, France. 2 Institut de Physique Theorique, Université de Fribourg, CH-1700 Fribourg, Switzerland. 3 Max-Planck-Institute of Colloids and Interfaces Theory Division Kantstrasse 55, D-14513 Teltow-Seehof, Germany 4 BANCOTEC GmbH, Calwerstraße...

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Static Simulation of CNTFET-based Digital Circuits

   In this paper we implement a simple DC model for CNTFETs already proposed by us in order to carry out static analysis of basic digital circuits. To verify the validity of the obtained results, they are compared with those of Wong model, resulting in good agreement, but obtaining a lighter ensuring compile and shorter execution time, which are the main character...

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Colloquium Paper : Bak and Paczuski

Complexity originates from the tendency of large dynamical systems to organize themselves into a critical state, with avalanches or "punctuations" of all sizes. In the critical state, events which would otherwise be uncoupled become correlated. The apparent, historical corntingency in many sciences, including geology, biology, and economics, finds a natural interpretation as a self-organized cr...

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Bak to death with chemotherapy.

BH3 mimetics, such as AT-101, are designed to interfere with various antiapoptotic proteins such as bcl-2, bcl-XL, and mcl-1, thus activating Bax and Bak; these mimetics ultimately promote apoptosis through a complicated pathway (see figure). When a malignant lymphocyte is exposed to chemotherapy, modulation of the cellular apoptotic threshold through this pathway could significantly enhance cy...

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ژورنال

عنوان ژورنال: Marges

سال: 2013

ISSN: 1767-7114,2416-8742

DOI: 10.4000/marges.270